Orforglipron is glucagon-like peptide-1 (GLP-1RA) weight that increases the release of insulin from the pancreas by increasing the volume of insulin-producing beta cells and reducing the release of glucagon (a hormone that increases blood sugar levels). Primarily a weight loss drug, it works by slowing the movement of food from the stomach into the small intestine, resulting in increased satiety, reduced food intake, and more efficient energy expenditure.
DOSING CONSIDERATIONS
18-36 week cycle followed by 18-36 week washout period
May be taken at any time of day
Does not have to be taken while in a fasted state
There are no dosing-related water intake restrictions, as seen in previous oral GLP formulation
DOSING
To dose accurately, please purchase a pill splitter. We have included links to appropriate options below:
Week 1: 1/4 of a pill (1.5mg), once per day
Week 2: 1/2 of a pill (3mg), once per day
Weeks 3-6: 1 pill (6mg), once per day
Weeks 7-10: 2 pills (12mg), once per day
Weeks 11-14: 3 pills (18mg), once per day
Weeks 15-18: 4 pills (24mg), once per day
Weeks 19-22: 5 pills (30mg), once per day
Weeks 24-36: 6 pills (36mg), once per day
After 36 weeks, take a break for 18-36 weeks before starting new cycle