Vasoactive Intestinal Peptide (VIP) is a 28-amino-acid endogenous neuropeptide hormone found throughout the central nervous system, peripheral nerves, immune system, lungs, and gastrointestinal tract. It is a potent regulatory peptide widely distributed in the brain, lungs, immune cells, gut, cardiovascular system. It exerts its effects through cAMP signaling, vasodilation, immune modulation, neuroprotection, and anti-inflammatory cytokine balance. Key cellular actions include suppression of TNF-a, IL-6m IL-12, increases IL-10 (anti-inflammatory cytokine), regulates Th1/Th2/Th17 balance, and protects endothelial and epithelial barriers.
BENEFITS
Immune Modulation and Autoimmune Regulation (VIP is one of the strongest endogenous anti-inflammatory peptides)
- Suppresses autoimmune-driven inflammation
- Downregulates overactive macrophages and T-cells
- Promotes immune tolerance
- VIP does not broadly suppress immunity like steroids
Pulmonary and Respiratory Benefits (VIP is highly expressed in the lungs)
- Potent bronchodilator
- Reduces pulmonary inflammation
- Improves oxygen diffusion
- Protects alveolar epithelial cells
Neurological and Cognitive Effects (acts as a neurotrophic and neuroprotective peptide)
- Enhances cerebral blood flow
- Protects neurons from oxidative stress
- Supports myelin integrity
- Improves circadian rhythm regulation
Gastrointestinal and Motility Support (is essential for gut homeostasis)
- Relaxes smooth muscle
- Increases intestinal blood flow
- Enhances mucosal barrier integrity
- Reduces gut inflammation
Vascular and Cardiovascular Effects
- Strong vasodilator
- Improves endothelial function
- Reduces platelet aggregation
- Enhances microcirculation
Hormonal and Endocrine Effects (interacts with hypothalamic-pituitary signaling)
- Modulates ACTH and cortisol rhythms
- Influences prolactin release
- Support circadian hormone balance
- These effects are part of why VIP is often used in complex chronic illness protocols in late-stage disease
Off-Label Use (when used internasally and after inflammatory markers normalize, MARCoNS addressed, and mold/toxin exposure eliminated, VIP may be used for the following)
- Improved cognition
- Reduced fatigue
- Better exercise tolerance
- Improved oxygenation
- Restoration of quality of life
ADDITIONAL BENEFITS
- Immune modulation: VIP helps balance immune responses, making it helpful for autoimmune conditions, chronic inflammation, and immune deficiencies
- Respiratory health: VIP can significantly improve lung function and reduce inflammation, which benefits those with asthma or mold-related illnesses
- Brain function and cognition: by promoting blood flow and reducing neuroinflammation, VIP supports cognitive function and may help with brain fog and fatigue
- Gut health: helps regulate gut motility and reduce intestinal inflammation
- Cardiovascular support: it improves circulation by dilating blood vessel
VIP HAS THERAPEUTIC VALUE IN TREATING THE FOLLOWING:
- Rheumatoid arthritis
- Multiple sclerosis
- Inflammatory bowel disease
- IBS (especially constipation-predominant)
- Sarcoidosis
- Traumatic Brain Injury (TBI)
- Autoimmune lung disease
- Chronic inflammation
- Mold toxicity
- Respiratory disorders
- Oxygen delivery
- Mucosal repair
- Alvelar ptrotectom
- Asthma
- Gut ischemia
- Post-infectious dysmotility
- Cognitivie fatigue
- Long COVID
- Osteoarthritis
- Oxidative stress
- Tissue repair
- Brain fog
- Seasonal allergies
- COPD
- Pulmonary hypertension
- Microvascular dysfunction
- Raynaud-like conditions
- ARDS
- Chronic fatigue
- Viral infections
- Cardiovascular health
- Digestive discomfort
- Neuroinflammation
- Circadian rhythm regulation
- Autoimmune disease
- Hormonal imbalances
- Free radical damage
- Immune deficiencies
POSSIBLE SIDE EFFECTS
- Flushing
- Headache
- Lightheadedness /dizziness
- Nausea
- Fatigue (during initial adaptive period)
- Hypotension
- Transient anxiety
- Increased urination
CONTRAINDICATIONS
- Active infection
- Uncontrolled autoimmune flare
- Cancer with angiogenesis risk
- Severe hypotension
- Pregnant or breastfeeding
CYCLE LENGTH AND DOSING CONSIDERATIONS
Short Cycle: 8-week cycle followed by 2-4 week washout period
Long Cycle: 3 months on followed by a 1 month washout period
Dosing 1-2 times per day: recommend administering in the morning or early afternoon to align with VIP’s natural role in regulating circadian rhythms, energy levels, and cellular function
Dose daily for the duration of the cycle
Dose in a fasted state
Must be conscientious about remaining well-hydrated
Subcutaneous Administration
DOSING PROTOCOLS
8-Week Protocol
Mix with 2.5mL (or 250 units ) of BAC water
- First day: 3 units (100mcg), increase dose as needed up to 6 units (200mcg)
- Increase dose slowly as needed- for example, add 1 unit every week or two until you reach 6 units (200mcg)
- Add 2nd dose any time after the first is tolerated without adverse side effects (taper second dose gradually from 100-200mcg as well)
3-Month Protocol
Mix with 2mL (or 200 units) of BAC water
- Take 10 units (200mcg), 1x/day, 5 days/week